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Drug Interaction of Tadalafil Tablet

Drug-Drug Interaction

DiaBeta

used for the treatment of erectile dysfunction (ED) in men. It is composed of Tadalafil and belongs to a group of drugs called phosphodiesterase 5 (PDE5) inhibitors. DiaBeta works by preventing the reuptake of an active ingredient in the body. This reuptake can be achieved when DiaBeta is taken in a slow, continuous, or high-fat diet. It should be noted that DiaBeta is not intended for immediate treatment of erectile dysfunction (ED) or any other condition. If you are suffering from low blood pressure or low blood pressure who should avoid taking DiaBeta tablets.

Cialis

is used to treat low blood pressure. It belongs to a group of drugs called phosphodiesterase 5 (PDE5) inhibitors. Cialis works by relaxing the blood vessels in your penis. This allows blood to flow into the penis and produce an erection when sexually aroused. It is composed of Tadalafil and Cialis belongs to a group of drugs called phosphodiesterase 5 (PDE5) inhibitors.

It works similarly to Tadalafil. Cialis is also used to treat erectile dysfunction (ED).

Drug-Food Interaction

Tadalafil Tablet should be taken on an empty stomach or at least 1 hour before a meal. It may be taken with or without food. DiaBeta Tablet should be taken with a meal. DiaBeta should be taken at least 1 hour before a meal.

It also works similarly to Tadalafil. Cialis should be taken in the dose and duration as advised by your doctor. It is recommended that you take it at the same time every day with a light meal.

Tadalafil

Tadalafil Tablet should be taken in the dose and duration as advised by your doctor. It is usually taken on an empty stomach or with a meal.

Cialis should be taken at the same time every day with a light meal.

Food-Medication Interaction

The Food and Drug Administration (FDA) has approved the use of Tadalafil (Cialis) Tablets in their approved uses. The tablets should be swallowed whole with a glass of water. Do not chew or crush the tablets. Stomach upset, diarrhea, nausea, and vomiting may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Disease Interaction

The use of DiaBeta Tablet caused a slight increased risk of developing systemic lupus erythematosus (Lupus). Lupus can be prevented or corrected by the intake of a dose of DiaBeta Tablet, as the drug belongs to a group of medications called anti-ulcer medications.

Prevention

You may inform your doctor regarding the use of this medicine in your patients' case in which an effective prevention or treatment for your patients' diseases is required. Your doctor will decide the dose, duration, and kind of your prescribed treatment. Your doctor may adjust your treatment or prescribe a different treatment for your patients' diseases. Your doctor will not be able to prescribe or use this medicine without your consultation and consent.

Side Effect

The side effects of DiaBeta Tablet have been described in the medical literature.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

Ketoconazole, itraconazole (used to manage fungal infection)
Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

ental flushing is a common complaint of users. This>:

You may experience hearing loss or other symptoms when taking this medicine while you are using this medicine- your healthcare provider will assess your symptoms and if they interfere with the treatment.
If you experience any of the symptoms, stop taking this medicine, or get back to regular use as normal, stop using this medicine, and seek medical help immediately.

C.

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness. Here are the key tadalafil-food interactions to be aware of:

: While taking Cialis, you may experience low doses of alcohol like lightheadedness, decreased need for light diets, or increased dizziness or lightheadedness. If you experience side effects like decreased need for light diets, tadalafil might be required for your treatment.

Interactions

A. Top Drug-Drug Interactions:

Other Drug-Drug interactions:

Ketoconazole, itraconazole (used to manage fungal infection)
Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.

EU Antic drugeca reLopressor (atomolizine)

C.

Cialis (tadalafil) can interact with certain foods and beverages, so using it in combination with these should improve results.

Grapefruit and Grape Juice: may enhance the levels of tadalafil by interfering with its metabolism. These products are known to increase tadalafil levels by a factor of 2 or more, causing side effects like headaches or dizziness.
: Though not a direct interaction, combining Cialis with grapefruit or grapefruit juice PDE5 inhibitors may enhance the blood pressure-lowering effects of these medications, which can cause symptoms like dizziness or fainting in sensitive individuals.

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References

1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.

2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/

3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf

4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36

5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs

Central Government. Treatment for erectile dysfunction. [Revised in November 2009] [Accessed on November 08th, 2023]https://www.chg.gov.

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